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Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells.
Yap CS, Sinha RA, Ota S, Katsuki M, Yen PM. Yap CS, et al. Biochem Biophys Res Commun. 2013 Nov 1;440(4):635-9. doi: 10.1016/j.bbrc.2013.09.116. Epub 2013 Oct 5. Biochem Biophys Res Commun. 2013. PMID: 24103759
Furthermore, we identified and characterized two novel TH-regulated target genes that were downstream of miR-181d signaling: caudal type homeobox 2 (CDX2) and sterol O-acyltransferase 2 (SOAT2 or ACAT2). CDX2, a known positive regulator of hepatocyte differen …
Furthermore, we identified and characterized two novel TH-regulated target genes that were downstream of miR-181d signaling: caudal type hom …
Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors.
Guo D, Lu M, Hu X, Xu J, Hu G, Zhu M, Zhang X, Li Q, Chang CC, Chang T, Song B, Xiong Y, Li B. Guo D, et al. Acta Biochim Biophys Sin (Shanghai). 2016 Nov;48(11):980-989. doi: 10.1093/abbs/gmw091. Epub 2016 Sep 29. Acta Biochim Biophys Sin (Shanghai). 2016. PMID: 27688151 Free PMC article.
In our previous work, we found that the high-level expression of human ACAT2 gene with the CpG hypomethylation of its whole promoter was synergistically regulated by two transcription factors Cdx2 and HNF1alpha in the intestine and fetal liver. ...Furthermore, ChIP …
In our previous work, we found that the high-level expression of human ACAT2 gene with the CpG hypomethylation of its whole promoter …
Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.
Song BL, Wang CH, Yao XM, Yang L, Zhang WJ, Wang ZZ, Zhao XN, Yang JB, Qi W, Yang XY, Inoue K, Lin ZX, Zhang HZ, Kodama T, Chang CC, Liu YK, Chang TY, Li BL. Song BL, et al. Biochem J. 2006 Mar 15;394(Pt 3):617-26. doi: 10.1042/BJ20051417. Biochem J. 2006. PMID: 16274362 Free PMC article.
These results provide a molecular mechanism for the tissue-specific expression of ACAT2 in intestine. In normal adult human liver, CDX2 expression is not detectable and the ACAT2 expression is very low. In the hepatoma cell line HepG2 the CDX2 expressi …
These results provide a molecular mechanism for the tissue-specific expression of ACAT2 in intestine. In normal adult human liver, …
Preparation of an anti-Cdx-2 antibody for analysis of different species Cdx-2 binding to acat2 promoter.
Song BL, Qi W, Wang CH, Yang JB, Yang XY, Lin ZX, Li BL. Song BL, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Jan;35(1):6-12. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003. PMID: 12518221 Free article.
Most notably, we found that the Cdx-2 in human intestine cell line Caco-2 is expressed in a differentiation-dependent manner and can efficiently bind to the mouse and human acat2 (acyl-coenzyme A: cholesterol acyltransferase 2) promoter regions, suggesting that the transcr …
Most notably, we found that the Cdx-2 in human intestine cell line Caco-2 is expressed in a differentiation-dependent manner and can efficie …